Personal investigador col·laborador d'IrsiCaixa: Jon Izquierdo Pujol, Javier Martínez Picado, Judith Dalmau Moreno, Victor Urrea Gales, Lidia Garrido Sanz.
Multi-OMICS identification and validation of mechanisms triggered by immune interventions aimed at reducing the size of the replication competent reservoir
This project explores a new strategy to eliminate the latent HIV reservoir using antiCD4-CAR CD8+ T cells. This approach mimics the allo-reactive effect of transplants but without their risks, specifically targeting infected CD4+ cells while preserving the rest of the immune system. Experiments in in vitro and in vivo models will help validate this strategy as a step toward a potential HIV cure.
Novel therapeutic agents to block interactions between enveloped viruses and myeloid cells: combating the settlement of infections (BLOCKER-PRO)