Personal investigador col·laborador d'IrsiCaixa: Jon Izquierdo Pujol, Javier Martínez Picado, Judith Dalmau Moreno, Victor Urrea Gales, Lidia Garrido Sanz.
Multi-OMICS identification and validation of mechanisms triggered by immune interventions aimed at reducing the size of the replication competent reservoir
This project explores a new strategy to eliminate the latent HIV reservoir using antiCD4-CAR CD8+ T cells. This approach mimics the allo-reactive effect of transplants but without their risks, specifically targeting infected CD4+ cells while preserving the rest of the immune system. Experiments in in vitro and in vivo models will help validate this strategy as a step toward a potential HIV cure.
Allogeneic Stem Cell Transplantation in HIV-1 Infected Individuals (IciStem)
Annemarie Wensing (University Medical Center Utrecht)
Participating entities
IrsiCaixa AIDS Research Institute, University Medical Center Utrecht, Gregorio Marañón Hospital, Churchill Hospital at Oxford University, Institut Pasteur (Paris), University Medical Center Hamburg-Eppendorf, Cellex (Dresden)