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SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis.

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Methods: SAMHD1 expression was downregulated in ovarian cancer cell lines OVCAR3 and SKOV3 by RNA interference. Gene and protein expression changes in immune signalling pathways were assessed. SAMHD1 expression in ovarian cancer patients was evaluated by immunohistochemistry and survival analysis was performed according to SAMHD1 expression.

Results: =0.01 and 0.04, respectively).

Conclusion: =0.01 and 0.04, respectively).

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