Projects

IrsiCaixa collaborator researchers: Joan Pagès i Oliveras, Elisabet García Rodríguez

The cause of viral immunopathogenesis in lymphoid tissue is unknown. We study cell death, activation and inflammation mechanisms in ex vivo cultures of lymphoid tissues, biopsied rectal tissue of HIV+ individuals and rhesus macaque lymphoid tissues.

BCG intravesical instillations play a key role in treating superficial bladder cancer by reducing recurrence and limiting progression. Despite its proven effectiveness, however, a significant proportion of patients are non-responders and so exposed to an increased risk of recurrence and progression. Unfortunately, no early response marker is available as yet in clinical practice. The objective is to identify factors that predict response to bladder treatment with BCG.