Julià Blanco Arbués
Julià Blanco (PhD in Biochemistry, University of Barcelona (UB), 1994) leads the Cell Virology and Immunology (VIC) group at IrsiCaixa. He has extensively studied the role of the HIV envelope glycoprotein (Env) in virus-cell or cell-to-cell interactions and HIV cytopathicity in a translational environment. In vivo, he has explored the mechanisms involved in CD4 T-cell depletion, analysing the contribution of virological and immunological factors that modulate CD4 and B-cell survival. In parallel, his team has developed experimental models for the analysis of cell-to-cell HIV transmission and Env-induced cell death. Knowledge generated regarding the Env function has also proved useful in analysing anti-Env drug and anti-Env antibody mechanisms of action and in contributing to a better understanding of antibody protection from HIV acquisition and spread.
Dr. Blanco is co-founder of AlbaJuna Therapeutics SL, an IrsiCaixa spin-off whose main activity is the development of synthetic antibodies against HIV, and associate professor at the Chair of Infectious Diseases and Immunity of UVIC-UCC.
Impact of Dolutegravir plus Lamivudine as First-Line Antiretroviral Treatment on HIV-1 Reservoir and Inflammatory Markers in Peripheral Blood.
NSGS mice humanized with cord blood mononuclear cells show sustained and functional myeloid-lymphoid representation with limited graft-versus-host disease.
Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant.
Omicron XBB.1.16-Adapted Vaccine for COVID-19: Interim Immunogenicity and Safety Clinical Trial Results.
Production and Immunogenicity of FeLV Gag-Based VLPs Exposing a Stabilized FeLV Envelope Glycoprotein.