Publicacions
El coneixement generat a IrsiCaixa es comparteix amb la comunitat científica a través de la publicació d’articles a revistes científiques d’alt impacte.
Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.
Increased expression of SAMHD1 in a subset of HIV-1 elite controllers.
Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.
Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.
New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.
Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo.
Computational studies identifying entry inhibitor scaffolds targeting the Phe43 cavity of HIV-1 gp120.
Insights from host genomics into HIV infection and disease: Identification of host targets for drug development.
HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.
Nucleotide embargo by SAMHD1: a strategy to block retroviral infection.