Publicaciones
El conocimiento generado en IrsiCaixa se comparte con la comunidad científica a través de la publicación de artículos en revistas científicas de alto impacto.
Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages.
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity.
Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.
Increased expression of SAMHD1 in a subset of HIV-1 elite controllers.
Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.
Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.
Characterization of the influence of mediator complex in HIV-1 transcription.
p21 regulates the HIV-1 restriction factor SAMHD1.
Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo.