HIV Pathogenesis

HIV PATHOGENESIS

Principal Investigator: José Esté

Presentation

Our group focuses on three main lines of research:

1. Identification of new cellular cofactors of viral infections. Our work over the past few years has focused on the study of cell targets as an antiviral intervention strategy and on validation of these targets in cohorts of HIV patients. This work has allowed us to build a portfolio of cellular factors at different stages of development: the identification and validation of new targets and the monitoring of drugs approved for treatment and technology transfers through reports to pharmaceutical companies and the filing of patents. Our laboratory has focused particularly on the study of cell control and proliferation mechanisms associated with HIV-1’s capacity for replication, identifying targets that, as well as acting on viral restriction factors, modulate the cell cycle and the proliferation of cells susceptible to infection. We have found that the cells of some HIV-positive patients are capable of spontaneously reactivating viral production or may respond differently to reactivation stimuli. Our goal is to define the mechanisms that contribute to cell proliferation, the role of cell proliferation in perpetuating the infectious viral reservoir, the relationship between viral proliferation and integration processes and the possible application of a treatment that selectively attacks latently infected cells while helping eradicate HIV from the infected organism.

2. Study of the viral-entry and between-cell transfer mechanism. HIV needs cell activation and inter- and intra-cellular signalling mechanisms to ensure productive replication and chronic infection. In the entry process, and particularly in cell-to-cell transmission, different receptors play an important role, with chemokines and cytokines modulating cell surface expression and the cell activation necessary for viral replication. Our aim is to deepen understanding of the mechanisms of interaction between HIV and the target cells admitting HIV entry and the subsequent process of viral replication. 

3. New antiviral development. We continue to screen and characterize the antiviral activity of new compounds, placing special emphasis on the development of active compounds against viral strains resistant to other drugs and on the validation of new therapeutic targets based on viral infection cellular cofactors.

Keywords: Pathogenesis, Immunity, Antiviral Response, Antiviral, resistance, Cure
Principal Investigator

José Esté

Dr. Esté’s laboratory focuses on the study of cofactors associated with HIV-1 and their links to AIDS pathogenesis with a view to how this information might allow the development of new therapeutic strategies. Dr. Esté has a doctorate in Medical Science from the Katholieke Universiteit...

Curriculum

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Irsi Caixa

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